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CMAJ : Canadian Medical Association... Jan 2007
Topics: Aged; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Electric Stimulation; Electromyography; Female; Humans; Lambert-Eaton Myasthenic Syndrome; Tomography, X-Ray Computed; Ulnar Nerve
PubMed: 17200388
DOI: 10.1503/cmaj.060767 -
Journal of Clinical Pathology Jul 1971
Topics: Animals; Asbestos; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Mesothelioma; Neoplasms
PubMed: 5571854
DOI: 10.1136/jcp.24.5.481-d -
Thorax May 1982A study of 336 patients with bronchogenic carcinoma was carried out in Chandigarh, Northern India. The findings suggest that its epidemiology differs in several respects...
A study of 336 patients with bronchogenic carcinoma was carried out in Chandigarh, Northern India. The findings suggest that its epidemiology differs in several respects from that in Western countries. Almost a third of all patients and 94.4% of the 54 women had never smoked. The peak frequency of bronchogenic carcinoma occurred between the ages of 51 and 60 years, 14.6% of the patients being aged less than 41 years. Of the 232 smokers and ex-smokers, 48.3% had smoked only cigarettes, 28.4% only bidis (made of naturally cured tobacco), 19.8% both cigarettes and bidis, and 3.4% hukkas. There was a clear association between duration of smoking and frequency of carcinoma. Tumours were classified in 287 (85%) of the patients. Squamous-cell carcinoma was relatively more frequent (32.4%) than any other tumour type and occurred almost exclusively in smokers. Adenocarcinoma was found in 13.2% of patients and was the most frequent tumour in non-smokers. No differences of histological type were found between cigarette smokers and bidi smokers.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Humans; India; Lung Neoplasms; Male; Middle Aged; Smoking; Time Factors
PubMed: 7112470
DOI: 10.1136/thx.37.5.343 -
The European Respiratory Journal Apr 2002Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer... (Review)
Review
Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females. In the USA it causes more deaths than cancers of the colon, breast and prostate combined. Disappointingly, in a recent UK survey of improvements in cancer survival, carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.
Topics: Biopsy, Needle; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Neoplasm Staging; Solitary Pulmonary Nodule; Tomography, Emission-Computed; Tomography, X-Ray Computed
PubMed: 11999004
DOI: 10.1183/09031936.02.00280002 -
The Journal of Thoracic and... Mar 2001Bronchogenic carcinoma in close proximity to or involving the carina remains a challenging problem for thoracic surgeons. The operative procedures to allow complete...
OBJECTIVE
Bronchogenic carcinoma in close proximity to or involving the carina remains a challenging problem for thoracic surgeons. The operative procedures to allow complete resection are technically demanding and can be associated with significant morbidity and mortality. Little is known about long-term survival data to guide therapy in these patients.
METHODS
We conducted a single-institution retrospective review.
RESULTS
We have performed 60 carinal resections for bronchogenic carcinoma: 18 isolated carinal resections for tumor confined to the carinal or proximal main stem bronchus; 35 carinal pneumonectomies; 5 carinal plus lobar resections, and 2 carinal resections for stump recurrence after prior pneumonectomy. Thirteen patients (22%) had a history of lung or airway surgery. The overall operative mortality was 15%, improved from the first half of the series (20%) to the second half (10%), and varied according to the type of resection performed. Adult respiratory distress syndrome was responsible for 5 early deaths, and all late deaths were related to anastomotic complications. In 34 patients, all lymph nodes were negative for metastatic disease; 15 patients had positive N1 nodes, and 11 patients had positive N2/N3 nodes. Complete follow-up was accomplished in 90%, with a mean follow-up of 59 months. The overall 5-year survival including operative mortality was 42%, with 19 absolute 5-year survivors. Survival was highest after isolated carinal resection (51%). Lymph node involvement had a strong influence on survival: patients without nodal involvement had a 5-year survival of 51%, compared with 32% for patients with N1 disease and 12% for those with N2/N3 disease.
CONCLUSIONS
This constitutes one of the largest single-institution reports on carinal resection for bronchogenic carcinoma involving the carina. Morbidity and mortality rates are acceptable. The overall survival including operative mortality is 42%. Positive N2/N3 lymph nodes may be a contraindication to surgery because of poor prognosis.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Carcinoma, Bronchogenic; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Child; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Retrospective Studies; Survival Analysis; Treatment Outcome
PubMed: 11241081
DOI: 10.1067/mtc.2001.112832 -
Revista Portuguesa de Pneumologia 2003In the present paper, the authors reviews the endocrine and metabolic manifestations in bronchogenic carcinoma. Disorders as paraneoplastic syndromes (hypercalcemia,... (Review)
Review
In the present paper, the authors reviews the endocrine and metabolic manifestations in bronchogenic carcinoma. Disorders as paraneoplastic syndromes (hypercalcemia, syndrome of inappropriate antidiuretic hormone, carcinoid and Cushing's syndromes) and others endocrinopathies are discussed. Hypertrophic pulmonary osteoarthropathy is briefly reviewed.
Topics: Biomarkers, Tumor; Carcinoma, Bronchogenic; Hormones; Humans; Lung Neoplasms; Paraneoplastic Syndromes
PubMed: 14685636
DOI: No ID Found -
BMJ Case Reports Dec 2014
Topics: Carcinoma, Bronchogenic; Female; Humans; Lung Neoplasms; Middle Aged; Pulmonary Atelectasis
PubMed: 25498809
DOI: 10.1136/bcr-2014-207844 -
Journal of Thoracic Oncology : Official... Feb 2010
Topics: Adenocarcinoma; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Multiple Primary; Survival Rate
PubMed: 20101142
DOI: 10.1097/JTO.0b013e3181c81500 -
Thorax Sep 2004Bulky endobronchial tumours in patients with lung cancer are difficult to treat. Brachytherapy and photodynamic therapy (PDT) are variably effective, and the combination...
BACKGROUND
Bulky endobronchial tumours in patients with lung cancer are difficult to treat. Brachytherapy and photodynamic therapy (PDT) are variably effective, and the combination of these treatments is not often recommended. However, cell culture studies and animal studies indicate a possible synergistic effect of combining PDT with ionising radiation. We assessed the safety and effectiveness of combined brachytherapy and PDT in patients with bulky endobronchial lung cancer.
METHODS
Patients with histologically proven non-small cell bronchogenic carcinoma and bulky endobronchial tumours were treated using a combination of PDT (Photofrin, 2 mg/kg) and brachytherapy. Six weeks after PDT, brachytherapy was applied with five fractions of 4 Gy at weekly intervals. Follow up was performed with standard and autofluorescence bronchoscopy and tissue biopsies every 3 months.
RESULTS
Thirty two patients were treated. Tumours were extensive with lengths ranging from 10 to 60 mm along the bronchus and estimated volumes ranging from 40 to 3500 mm3. At a mean follow up of 24 months, 26 patients were free of residual tumour and local recurrence. The remaining patients received a second treatment with PDT, brachytherapy, Nd:YAG laser coagulation, or external beam radiation. Distant metastases (lung, lymph node) developed in two of the six patients. Currently, all 32 patients are well. There is no evidence of residual or local recurrent endobronchial cancer in 28 patients and none had severe complications.
CONCLUSION
The combination of PDT and brachytherapy for treating patients with lung cancer and extensive endobronchial tumour is safe and, in this study, had excellent therapeutic efficacy.
Topics: Aged; Aged, 80 and over; Brachytherapy; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Photochemotherapy; Treatment Outcome
PubMed: 15333857
DOI: 10.1136/thx.2003.013599 -
Canadian Respiratory Journal 2012To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas...
OBJECTIVE
To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy.
METHODS
Using a case-control design, 186 formalin-fixed paraffin-embedded blocks of bronchial tissue (136 cases, 50 controls) obtained from patients who underwent routine nonfluorescence bronchoscopy between 2004 and 2005 were studied.
RESULTS
ASD occurred at a higher frequency in patients with neoplastic lesions compared with those without neoplastic lesions (28 of 136 versus one of 50). ASD was also more prevalent in patients with squamous cell carcinoma compared with other neoplasms. Seventy six per cent of the ASD patients (22 of 29) smoked cigarettes. The morphology of ASD on hematoxylin and eosin- and CD31-stained sections was characterized by prominent microvasculature and capillary projections closely juxtaposed to variable degrees of dysplasia in all of the bronchogenic carcinoma specimens, and to metaplasia in one case in the control group.
CONCLUSION
ASD is a unique morphological entity that should be considered by pathologists even on bronchoscopic biopsies from patients who undergo white light bronchoscopy. The presence of ASD may represent a risk biomarker of bronchogenic carcinoma in screening programs and in chemoprevention of lung cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Bronchoscopy; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Female; Humans; Hyperplasia; Lung Neoplasms; Male; Metaplasia; Middle Aged; Neoplasms, Squamous Cell; Neovascularization, Pathologic; Precancerous Conditions; Respiratory Mucosa; Small Cell Lung Carcinoma; Smoking
PubMed: 22679613
DOI: 10.1155/2012/343954